He is active in clinical research in particular in the fields of the interventional treatment of coronary artery disease (acute coronary syndromes), carotid and peripheral artery disease, and valvular heartdisease (transcatheter aortic and mitral valve interventions). I contributed to several multi-center clinical trials as Primary Investigator or Co-Primary Investigator, including ATLANTIS, GALILEO,BRAVO 2/3, PLATINUM PLUS, ACCOAST, ROSPREC, SPIRIT-WOMAN, INSTANT,RINSPIRATION, GENOUS, STEEPLE, GISSOC II, ON-TIME, BLAZE, FINESSE. He also initiated or contributed to numerous spontaneous clinical studies at his Institution