Stem Cell Research and Regeneration on Cardiology

Ischemic heart disease is the most common cause of death in the world. Myocardial infarction causes irreversible cardiomyocyte loss, which leads to heart failure and unfavorable remodeling. An objective of cardiac biology and regenerative medicine is to find fresh sources of cardiomyocytes and promote their development. Many types of putative cardiac stem cells (CSCs) have been identified to heal the wounded heart by differentiating into new cardiomyocytes within the last decade. Some of these CSCs have been successfully transferred from the bench to the bedside, with promising therapeutic results. Recent basic research investigations on stem cell tracing, on the other hand, have begun to cast doubt on their fundamental biology and mechanisms of action, raising major doubts about CSCs' myogenic potential. We examine the evolution of different types of CSCs over the last decade and provide an update on recent cell tracing research that have cast doubt on CSCs' origins and existence. Aside from the potential role.



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